Pharmaceutical distributors live and die by batch discipline. A wholesaler moving thousands of SKUs across schedule drugs, cold-chain lines, and multiple drug-license jurisdictions cannot afford to pick a near-expiry batch first, ship a schedule-H drug to an unlicensed retailer, or lose the temperature log a regulator asks for at audit. ERPNext ships strong foundations here: Batch and Serial No DocTypes, Stock Ledger Entry, and auto-batch selection with a FEFO option. But native runs out of road at the compliance edge — there is no first-class drug-license register per customer, no schedule-drug gating on the Sales Order, no expiry quarantine workflow, and no cold-chain excursion capture tied to the batch you actually shipped. Teams end up bolting this onto custom fields and spreadsheets that break at scale.

ECOSIRE builds a proper Frappe app that closes those gaps as native ERPNext, not a bolt-on. We add DocTypes such as Drug License (number, authority, schedule scope, valid-from/valid-to, linked Customer/Supplier), Schedule Drug Classification on the Item, and Cold Chain Log linked to Batch and Delivery Note. FEFO is enforced in a hooks.py doc event on Delivery Note and Sales Invoice validate — a server script that overrides auto-batch selection to pick strictly by earliest expiry_date and hard-blocks any manual batch pick that would ship stock closer to expiry than an available alternative. Schedule-drug sales are gated the same way: a before_submit hook checks the customer's active Drug License covers the item's schedule and is not expired, throwing a frappe.ValidationError otherwise, so a non-compliant dispatch cannot be posted.

The rest is wired to ERPNext's own primitives so it stays upgrade-safe. Expiry management runs on a scheduler_events daily job that flags batches inside a configurable shelf-life window, auto-creates a quarantine Stock Entry (material transfer to a blocked warehouse), and emails the compliance role. Cold-chain excursions are captured via client scripts and a whitelisted REST method (@frappe.whitelist()) so IoT sensors or a mobile app can POST readings against a batch; an out-of-range reading raises an alert and can hold the batch. Everything respects Frappe permissions — a Compliance Officer role profile with row-level permission on Drug License and Cold Chain Log, so warehouse staff see stock but only compliance can override a quarantine. Print formats produce the batch-and-expiry-stamped invoice and the regulatory dispatch register your inspectors expect.

Because this is build-to-order, nothing is a generic download. We start with a scoping call to map your schedules, license jurisdictions, warehouse layout, and cold-chain SLAs, then build against your ERPNext v15 or v16 site. You get installable source for your version, deployment on your bench, UAT on a staging site, and a git repo handover — delivered typically in 2 to 4 weeks from confirmed scope, with a post-go-live support window so the first real regulatory cycle is covered.